Researchers have successfully used 'bioinks' containing living nerve cells (neurons) to print 3D nerve networks that can grow in the laboratory and transmit and respond to nerve signals.
Monash University Engineering researchers have successfully used"bioinks" containing living nerve cells to print 3D nerve networks that can grow in the laboratory and transmit and respond to nerve signals.
Professor John Forsythe of the Department of Materials Science and Engineering, who is leading the research, said while two-dimensional nerve cell cultures have previously been used to study the formation of nerve networks and disease mechanisms, those relatively flat structures don't reflect the way neurons grow and interact with their surroundings.
"We found that the projections growing from neurons in the printed 'grey matter' or cellular layer readily grew through the 'white matter' layer and used it as a 'highway' to communicate with neurons in other layers. Sensitive electrophysiological measurements confirmed spontaneous nerve-like activity taking place in the 3D neuronal networks in addition to responses evoked by electrical and drug stimulation.
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