Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form.
Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers at Karolinska Institutet in Sweden now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form.
The NO is formed in the endothelium, the tissue that constitutes the inner lining of blood vessels. For almost 40 years, the hypothesis has been that it then diffuses as a gas, spreading out randomly until it encounters an enzyme called guanylyl cyclase in the vascular smooth muscle, upon which the vessel relaxes. It is a journey over a distance of less than a millimetre, but it is a long way for a molecule.
The researchers found that NO-ferroheme significantly expands the blood vessels of mice and rats, and that in controlled experiments directly activates guanylyl cyclase, thus acting as a signal substance in the signal cascade.
Norge Siste Nytt, Norge Overskrifter
Similar News:Du kan også lese nyheter som ligner på denne som vi har samlet inn fra andre nyhetskilder.
Researchers present novel principle for nitric oxide-mediated signaling in blood vesselsAlthough a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers at Karolinska Institutet in Sweden now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form. Their findings are presented in the journal Nature Chemical Biology.
Les mer »
Yale Researchers Discover New Bacterial Strain Causing Widespread Newborn Deaths and Disease in UgandaIn 2007, Yale pediatric neurosurgeon, Dr. Steven Schiff, visited his colleague Dr. Benjamin Warf at the CURE Children’s Hospital in Uganda. The scenes at the hospital stunned him: every day mothers came from all over the country carrying infants with enlarged heads, desperate for a cure. The moth
Les mer »
Researchers reveal dominant source of atmospheric mercury in the ArcticA research team led by Prof. Xie Zhouqing and Prof. Le Fange from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) revealed that the Marginal Ice Zone (MIZ) is a dominant source of atmospheric gaseous elemental mercury (GEM), and proposed a mechanism for the summertime peak of GEM in the Arctic. Their work was published in Nature Communications.
Les mer »
Protected nature reserves alone are insufficient for reversing biodiversity loss, researchers sayBiodiversity is dwindling at a rapid pace across the globe. As one key remedy, we are protecting areas around the world, hoping that they will suffice to save what is left. While protected areas have undoubtedly contributed to slowing the overall biodiversity loss, it is unclear how well they work across multiple species concurrently. To explore this, researchers at the University of Helsinki examined changes in the occurrence of hundreds of species within and outside of protected areas.
Les mer »
Researchers unveil comprehensive database of published microbial signaturesA new study published by researchers from the CUNY Institute for Implementation Science in Population Health (ISPH) at CUNY SPH and colleagues presents BugSigDB, a community-editable database of manually curated microbial signatures from published studies.
Les mer »
UCLA researchers plan to deeply examine health impacts of Aliso Canyon gas leakMany San Fernando Valley residents felt County Department of Public Health didn’t go far enough to assess human damage.
Les mer »