Researchers found that a derivative of the natural compound indirubin offers a new approach to treating glioblastoma in mice, which will inform future research in humans. Scientists have discovered that a drug derived from the natural compound indirubin shows promise in treating malignant brain t
A new study has revealed the potential of a drug derived from indirubin, a natural compound used in traditional Chinese medicine, in treating malignant brain tumors in mice. Published in, the research highlights how a formulation of indirubin improved mice’s survival rates and moved the drug closer to clinical trials with human participants. Scientists from various institutions, including Brown University and Harvard Medical School, collaborated on the study.
A new study shows how a drug made from a natural compound used in traditional Chinese medicine works against malignant brain tumors in mice, creating a promising avenue of research for glioblastoma treatment., researchers showed how a formulation of the compound, called indirubin, improved the survival of mice with malignant brain tumors.
In addition to scientists from Brown’s Legorreta Cancer Center and School of Engineering, the team included researchers from the department of neurosurgery at Brigham and Women’s Hospital/Harvard Medical School and Phosphorex, Inc./Cytodigm, Inc. As the scientists continued to research the compound, they were contacted by the Massachusetts-based biomedical company Phosphorex, which develops technology to improve pharmaceutical formulations. Phosphorex had patented a formulation of indirubin, called 6’-bromoindirubin acetoxime , which made the compound easier to use as an injectable cancer treatment.
“The drug impacted the immune system in these mouse experiments in a way that we think could enhance clinical immunotherapy in humans,” explained Lawler, whose lab therapeutic approaches for the treatment of brain cancer.
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