A new study develops 'environment-modulating' drugs that reinvigorate T-cells to once again destroy cancer cells.
T-cells, typically thought to be anti-cancer, can switch sides and work against us in the right environment , according to aIn light of this, the study went a step further by proving that altering the local environment around the tumor could "reinvigorate" T-cells to once again destroy cancer cells.This discovery is unexpected because many extensive studies before this believed that most worn-out T-cells' properties were "irreversible.
, they actively switch off other cells in the area by altering the environment around them. "In other words, exhausted T-cells aren't just failing to work"The key takeaway from our work is that our immune system is critically sensitive to its local environment. In the right environment, cells typically thought to be anti-cancer can switch sides and work against us," he explained.work against us also opens up new immunotherapy treatment options.
He added that the group is eager to create medicines targeting patients' suppressive nature of T-cells. Interestingly, these would be examined with diseases other than cancer.
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