The final release of the Human Genome Project in 2003 left 8 percent of the genome behind. Now, a grassroots effort has closed the gaps. Find out more by clicking the link below.
. Their sequence has not only corrected errors in prior references but revealed that these absent sections may be far more significant than previously imagined — they may play a much larger role in our genome, and in understanding diseases like cancer, than previously expected. “I think we’re going to find there’s more variation in that 8 percent than in the 92 percent we’ve been looking at,” Phillipy says.
These chunks of the genome weren’t previously surveyed because they were difficult to map and weren’t thought to contain genes. Yet we now know that these regions “present some of the most highly variable sequences in our human species,” Miga says.
One interesting feature: the centromeres, which play a major role in ensuring proper cell division. These arrangements of non-gene regions can give us insight into errors in cell division such as cancer, Miga adds.While mapping an additional 8 percent of a genome sounds more like a clean-up job than a paradigm shift, the researchers agree that nothing could be further from the truth.
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