Scientists Solve Century-Old Cell Division Mystery

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Scientists Solve Century-Old Cell Division Mystery
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A research team from Pohang University of Science and Technology unveiled the mechanism behind crossover interference during meiosis, solving a long-standing mystery in genetics. This breakthrough could revolutionize agricultural breeding by enabling precise control over crop traits, paving the way for improved disease resistance and productivity in plants.

A research team, consisting of Professor Kyuha Choi, Dr. Jaeil Kim, and PhD candidate Heejin Kim from the Department of Life Sciences at, has achieved a remarkable feat by unveiling the molecular mechanism responsible for crossover interference during meiosis, a biological pattern at the chromosome level.

Meiosis and crossover play pivotal roles in biodiversity and have significant implications in breeding where the selection and cultivation of superior traits in crops occur. Typically, most animal and plantexhibit a minimum of one and a maximum of three crossovers per a pair of homologous chromosomes.

The ability to control the number of these crossovers could lead to cultivating crops with specific desired traits. However, achieving such control has been challenging due to the ‘phenomenon of crossover interference.’ Crossover interference, where one crossover inhibits the formation of another crossover nearby along the same chromosome, was initially identified by fruit fly geneticist Hermann J. Muller in 1916.

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