Should You Mix and Match COVID-19 Booster Vaccines? Mixed Immunity, Explained by Doctors
mean that the vaccines don’t work. “We know that the full doses of the [COVID-19] vaccines are incredibly effective at preventing severe disease, hospitalizations, and deaths in almost everybody,” explains
, an infectious disease doctor, vaccine researcher, and assistant professor in the department of International Health at Johns Hopkins University.“In general, boosters do improve the immune response, no matter what booster you get,” Dr. Talaat says. But people who receive an adenovector vaccine, such as Johnson & Johnson in the United States orelsewhere, get the most substantial response when they receive an mRNA vaccine, like Pfizer or Moderna, as their booster, she notes.
“Probably, it is going to be more or less the same, except for Johnson & Johnson” as your initial vaccine, explains, professor of medicine at the Johns Hopkins University School of Medicine. “In that case, you want the booster to be mRNA.” “Personally, I received the same vaccine platform for the booster: Moderna and Moderna,” Dr. Johnston says. “If you received either Pfizer or Moderna initially, I would be happy sticking with the original vaccine. If you received Johnson & Johnson, you may consider doing an mRNA boost, based on the higher antibody levels that were seen in the clinical trials.”
“Some people may have other reasons for choosing one regimen over another, for instance, if people are more concerned about the very rare
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