Biologists have discovered why an enzyme is important for the survival of fruit flies, even though it can shorten their lives under certain conditions.
Nothing comes for free—this saying applies very well to the work of chameau. As researchers led by Axel Imhof from LMU's Biomedical Center Munich have demonstrated, the enzyme plays an important role in helping fruit flies to survive periods when food is in short supply. However, this comes at a cost: when there is plenty of food available, chameau has a life-shortening effect. The study is published in the journal.
"The complete absence of chameau results in fatal development defects," says Imhof."However, we managed to lower the enzyme levels to around a fifth of its normal levels without affecting viability under normal conditions to study it's role in stress response."Their results show that flies with low chameau levels are less well able to deal with hunger."When flies are starving, their bodies break down storage molecules such as glycogen and fats.
Furthermore, the scientists observed that flies with very low chameau levels were much thinner than wild types even when fed well."This means that these flies not only have a problem with the expenditure, but also with the storage of energy," explains Imhof. Comprehensive molecular analyses revealed that chameau mutations result in a failure to properly regulate the genes and proteins required for energy storage and expenditure."Based on research with the mouse chameau gene, we believe that similar mechanisms may also exists in vertebrates such as mice and humans" says Imhof. However, this would require further studies.
can lead to a longer lifespan," says Imhof. When conditions become unfavorable, however, the flies are unable to respond appropriately.
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