Spatial imaging of glycoRNA in single cells with ARPLA
A representative structure from the simulation with oxDNA, including the glycan probe, the RNA binding probe, the connector 1, and the connector 2. The circle of the connector 1 and the connector 2 tends to form a triangle structure, with two sides formed by DNA helix and one side formed by the ssDNA region in the connector 1;
Integrated heat of the ITC titration for Neu5Ac aptamer and Neu5Ac, the black line represents the binding curve fitted with the ‘one set of binding sites’ model; ARPLA-mediated glycoRNA imaging on the surface of HeLa, HL-60, and THP-1 cells. Scale bar: 20 μm , 10 μm ; Blotting of total RNA from SH-SY5Y cells after metabolic labeling with Ac4ManNAz, or SH-SY5Y cells without metabolic labeling;
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