Researchers have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors -- an advance that could transform cancer treatment. The promising findings involve CAR-T cell therapy, which supercharges the immune system to identify and attack cancer cells.
Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors -- an advance that could transform cancer treatment. The promising findings, reported today in, involve CAR-T cell therapy, which supercharges the immune system to identify and attack cancer cells.
Their specially designed gene enables the infused T cells to express synthetic CAR receptors on their surface. The CARs can recognize specific proteins, known as antigens, that protrude from cancer cells. Thanks to their new CARs, the T cells are able to home in on cancer cells and then switch to attack mode.
Simply attaching CAR-T cells to tumor cells isn't enough to kill them. CARs must also include a costimulatory protein to help activate T cells once they've made contact with cancer cells. Four of the five CAR-T cell therapies developed by Dr. Zang's lab used previously deployed costimulatory proteins. But their fifth therapy used a protein never before tried in CAR-T cell therapy. In 2015, Dr.
Dr. Zang plans to further develop TOP CAR into an"off-the shelf" platform that can simultaneously target B7-H3 as well as other tumor antigens and can readily be tailored for treating many different types of solid tumors. Einstein has intellectual property protection for a portfolio of Dr.
Cancer Lung Cancer Skin Cancer Lymphoma Pancreatic Cancer Prostate Cancer Immune System
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