The 15 Most Shocking Moments in Grey's Anatomy's First 15 Years
) fell in love with the effortlessly charming Denny Duquette as he awaited a much-needed heart transplant throughout the second half of season two, falling for him right along with her. And when her wild plan to cut his LVAD wire to move him up the transplant list failed spectacularly, resulting in his death in the season finale, it was confirmed that Grey's Anatomy was not here to give us the happy endings we wanted.
having sex with Izzie. In one of the most ludicrous moments in the show's history, Ghost Denny was used to signal to viewers and to Izzie herself that something was wrong. That something was ultimately proven to be stage IV metastatic melanoma, which had spread to, among other places, her brain.While fans were expecting Izzie to bite the bullet in the season five finale, the fact that no one could find George should've clued us into the fact that something was up with poor O'Malley.
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