Drugs that direct the body’s proteolytic capabilities towards cancer cells might overcome problems of treatment resistance.
Craig Crews , a biochemist at Yale University in New Haven, Connecticut, speaks with a postdoctoral chemist.The prognosis for prostate cancer today is bright — provided it is caught before it has spread. Once it has metastasized, the five-year survival rate plummets from almost 100% to around 30%., a class of hormones of which testosterone is the most common.
Enter a new contender: proteolysis-targeting chimaeras, or PROTACs. They are not just a new cancer treatment, but a new kind of drug. Most drugs have to remain bound to their target in order to maintain their effect, which means large doses are required to keep enough targets blocked, increasing the likelihood of side effects.
Another common resistance mechanism is the mutation of androgen receptors, which can cause them to become less selective and respond to other hormones, or even be activated by molecules that are normally inhibitory.
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