The attempt to map every human cell is revealing previously hidden patterns.
, an international collaboration aiming to catalog every cell in the body. It hints at the power of the Cell Atlas to illuminate how the raw information in our genes is used to assemble a living, breathing human.
With an almost omniscient view, Human Cell Atlas researchers can start to see how cells across the body use their genetic blueprint to create our life-sustaining organs. They can also begin to pinpoint how a single gene leads to a malfunctioning cell and then a full-body disease.
“If you think about it from a therapy point of view,” says Regev, “there is no point of fixing the muscle cells if it’s actually the new cell in the tissue that is broken.”With an atlas, mysterious features of a disease can suddenly make sense. Patients with Duchenne muscular dystrophy, who have a misformed protein normally used to help muscle tissue heal after use, sometimes experience excruciating gastrointestinal disorders. “It’s hard to explain it,” says Regev.
“This is a really striking example of how the human and the mouse are not the same,” says Regev. “When we develop medicines and so on, we often work a lot with mice—we have to—but it’s really important to know what’s the same and what is different.”
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