Imagine having a camera inside your DNA.
and genome engineering techniques, scientists can introduce a synthetic DNA region in an animal’s DNA. This region contains “genetically encoded DNA barcode arrays” called DNA tapes that record cellular changes in the form of mutations. Later, these recordings can be recovered via DNA sequencing.
DNA tapes are just one component of the DNA event recording system. It also comprises a molecular machine to sense what is going on inside and outside the cell, a writer system to transmit such information to the synthetic DNA tape by repurposing genome editing technologies, and a reader that reconstructs biological history usingAccording to the researchers, this entire DNA event recording system targets the synthetic DNA regions and therefore, it does not affect the original DNA or the.
When asked about other applications of DNA event recording, one of the authors of the study and Director of research at the University of British Columbia’s School of Biomedical Engineering , Nozomu Yachie told, “We still do not know how a single cell creates our complex mammalian body structures, deciphering this is simply exciting. Also, such information will be a new backbone resource of biology like Google map where we can map and integrate diverse biological knowledge.
He further added, “the same idea can be applied to study cancer progression and metastasis too and will derive hints to regulate various cancer diseases.”DNA event recording could increase our understanding of human biology and help us solve many mysteries
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