Three brain rejuvenation methods may exert their effects through the same molecule, at least partly, which could lead to therapies for cognitive decline.
Villeda and colleagues were interested in the immune system. “More and more research is pointing toward a link between the immune system, cognitive decline and diseases like Alzheimer’s,” Villeda says. Injecting PF4 into old mice returned their body’s immune systems to a more youthful state,, the team found.
The main limitation of the new studies is that few findings in mice translate into safe and effective therapies in people. But in humans, as in mice, PF4 declines with age, and human PF4 also improves cognition in mice, the researchers found.klotho improves cognition in aging monkeys
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