Discover how Japanese researchers are using tissue models to create a blood-brain barrier model and advance drug development.
Aiming to speed up the drug development process, a team of Japanese researchers has successfully created a blood-brain barrier model using modularized tissue produced from human cells.
The tiny cubic structure developed by the team known as “Tissue-in-a-CUBE” has the potential to advance drug discovery and replace animal models in pre-clinical research.. Nevertheless, it can occasionally be challenging to forecast a drug’s efficacy in humans as well as potential negative side effects due to variations between animals and humans.
In light of this, the RIKEN BDR research team created a new blood-brain barrier model by utilizing the CUBE-type technology that they have set up for the modularization of various human tissues. “We were happy to find that it accurately mimicked the real blood-brain barrier in terms of structure and function. Like the real barrier, it only allowed limited substances to pass through, and astrocytes and pericytes extended three-dimensionally beneath the sheet of endothelial cells, said Masaya Hagiwara, research lead of the project from RIKEN BDR, in a
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