To solve the mystery of long COVID, researchers look to an older disease

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To solve the mystery of long COVID, researchers look to an older disease
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The symptoms of long COVID appear almost identical to a condition known for decades: myalgic encephalomyelitis/chronic fatigue syndrome. Understanding the connections between the two could be key to helping people suffering from both.

Dr. Liisa Selin and Anna Gil watch as research technician Taeva Cohen prepares blood samples for analysis in the pathology lab at the UMass Chan Medical School.

She still has trouble breathing, moving and thinking clearly. It takes her hours to get out of bed and ready for the day. Selin studies the immune system. She also knows the devastating impact of chronic fatigue: She has lived with ME/CFS for 47 years. Selin often experiments on herself. A couple years ago, she looked at a sample of her own blood and found some immune cells behaving strangely. Later, when she looked at the blood of long COVID patients, she found the same phenomenon. The immune cells appeared exhausted from working too hard.

“ME/CFS research was definitely viewed by many as fringe and perhaps addressing a problem that didn't exist,” said Dr. David Systrom, a pulmonary and critical care physician at Brigham and Women’s Hospital. Doctors are already using some of the same drugs to treat ME/CFS and long COVID, Systrom said. But they can only treat symptoms, such as pain and exhaustion. They can't treat the diseases because so much about them remains a mystery.

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