Results from the STEP 5, testing semaglutide as an adjuct to behavioral interventions in adults with overweight or obesity, demonstrate sustained weightloss over a period of 104 weeks. ProfBatterhamMD seanwharton DrGeorgiaRigas
History of major depressive disorder within 2 years before screening.A Patient Health Questionnaire-9 score of ≥15 at screening.Suicidal ideation corresponding to type 4 or 5 on the Columbia-Suicide Severity Rating Scale within the past 30 days before screening.History or presence of chronic pancreatitis.Personal or first-degree relative history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma.) by the central laboratory at screening.
Any of the following: myocardial infarction, stroke, hospitalization for unstable angina or transient ischemic attack within the past 60 days before screening.Surgery scheduled for the duration of the trial, except for minor surgical procedures, in the opinion of the investigator.Known or suspected hypersensitivity to trial product or related products.Participation in another clinical trial within 90 days before screening.
Body weight, waist circumference and vital signs were measured at baseline; these measurements were repeated every 4 weeks until week 20, and every 8 weeks thereafter, until week 100 and week 104 . These parameters were also measured at the end-of-trial visit at week 111 . Height was measured at screening. HbA, fasting plasma glucose, lipids and C-reactive protein were measured at baseline and weeks 20, 52, 84, and 104; electrocardiograms were also performed at these time points.
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