The model offers valuable perspectives on the progression of AD and may speed up the testing of new treatments. The decline in cognitive function linked to Alzheimer's disease occurs as neurons start to die. This can result from faulty immune reactions and heightened inflammation in the brain, inst
Researchers have developed a 3D human cellular model to study the complex interactions between immune cells and brain cells in Alzheimer’s disease . The model has revealed how specific immune cells amplify brain damage in AD, offering new targets for potential therapies.
The team also identified the molecular mechanisms that drive the infiltration of T cells to the brain and showed that blocking these mechanisms reduced the destructive effects of T cell infiltration. “We hope our work contributes to developing a more physiologically relevant human Alzheimer’s disease model in a dish,” adds co–senior author Doo Yeon Kim, Ph.D., associate professor of Neurology at MGH.
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