An experimental HIV vaccine led to antibodies against the virus in 35 out of 36 volunteers, but whether this offers protection against the infection is unclear
As a result, many groups of researchers are seeking to develop vaccines that stimulate a type of immune cell called B-cells to generate so-called broadly neutralising antibodies. These work against parts of the HIV virus that vary little between strains.
When it comes to HIV, incorporating viral proteins into a vaccine may activate this subset of B-cells.at the University of Washington in Seattle and her colleagues recruited 48 volunteers without HIV to test a vaccine that stimulates B-cells to make HIV-specific broadly neutralising antibodies, based on laboratory and animal studies.
After the injections, all the participants regularly provided blood samples for 16 weeks. Of those who received either the low or high vaccine doses, 97 per cent had HIV-specific broadly neutralising antibodies at the end of the study. Antibody levels were similar across the participants who received either the high or low vaccine doses, but marginally higher among those who had the high doses.
Across all the participants, including those given the saline solution, 98 per cent experienced mild side effects, such as fatigue, headaches and tenderness at the site of injection.
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