Kansas City dominated from the start in the 44-21 season-opening win in Glendale.
David Brandt Associated Press GLENDALE — Patrick Mahomes threw for 360 yards and five touchdowns, lifting the Kansas City Chiefs to an impressive 44-21 road win over the Arizona Cardinals on Sunday in the opener for both teams.
Tight end Travis Kelce caught eight passes for 121 yards and a touchdown. It was his 30th career game with at least 100 yards receiving. Clyde Edwards-Helaire hauled in two touchdown passes. Kansas City — which is trying to make the AFC title game for a fifth straight season — had a 37-7 advantage by the fourth quarter.
The Cardinals came into Week 1 missing some of their best players. Three-time All-Pro receiver DeAndre Hopkins was suspended for the season's first six games after violating the NFL's performance-enhancing drug policy. Star defensive lineman J.J. Watt was inactive because of a calf injury.
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