Individuals with a higher BMI showed a weakened response to vitamin D supplementation, which could explain disparities in outcomes such as cancer, diabetes, and autoimmune diseases. Researchers from Brigham and Women's Hospital, a member of the Mass General Brigham healthcare system, have uncover
Vitamin D is an essential nutrient that plays a crucial role in maintaining good health. It helps the body absorb calcium, which is important for strong bones and teeth, and also helps regulate the immune system and maintain proper muscle function.
Vitamin D is an essential nutrient involved in many biological processes, most notably helping our body absorb minerals, such as calcium and magnesium. While some of the vitamin D we need is made in the body from sunlight, vitamin D deficiencies are often treated with supplementation.
“Most studies like this focus on the total vitamin D blood level,” said senior author JoAnn E. Manson, MD, DrPH, chief of the Division of Preventive Medicine at the Brigham and principal investigator of VITAL. “The fact that we were able to look at this expanded profile of vitamin D metabolites and novel biomarkers gave us unique insights into vitamin D availability and activity, and whether vitamin D metabolism might be disrupted in some people but not in others.
“This study sheds light on why we’re seeing 30-40 percent reductions in cancer deaths, autoimmune diseases, and other outcomes with vitamin D supplementation among those with lower BMIs but minimal benefit in those with higher BMIs, suggesting it may be possible to achieve benefits across the population with more personalized dosing of vitamin D,” said Manson. “These nuances make it clear that there’s more to the vitamin D story.
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