In the last few years, the deeply frustrating medical area of chronic migraine prevention has been revolutionized thanks to the discovery that a protein called calcitonin gene-related peptide, or CGRP, plays a role in the condition.
and are helping thousands of patients, we still don't entirely understand how CGRP acts on a cellular level, which is necessary to advance the treatments further.
Past studies on animal models have shown how CGRP is released under painful responses that trigger neurogenic inflammation. Squirt a few drops of capsaicin on the skin, for instance, and the body will respond by opening blood vessels and dishing out a world of hurt, largely thanks to the release of this particular protein.
Further tests using inhibitory molecules that target the production of tiny transport bubbles called endosomes helped flesh out the rest of the pathway.Endosomes carry the receptor into a position where it can signal the release of nitric oxide, which then triggers pain receptors which switch on when stressed by reactive oxygen.
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