Human inbreeding by the numbers. Geneticists can tell if your parents were closely related — and whether that will affect your health.
Among those people whose parents were related, the researchers picked out typical signs of human inbreeding, such as a few common health issues. Inbred children commonly displayed decreased cognitive abilities and muscular function, reduced height and lung function, and are at greater risk from diseases in general, they found. The inbred children are also at higher risk of rare recessive genetic disorders, though the researchers didn’t include any data on those.
The researchers found that inbreeding in humans causes physical and mental problems, though the severity of those effects was somewhat limited. The average for the seven traits that inbreeding negatively impacted in the study was between 0.3 and 0.7 standard deviations below the mean. For context, between 25 and 40 percent of people fall in that range normally, they say. So, inbreeding hasn’t necessarily caused people in the UK Biobank irreparable harm.
The team was also just looking for the most extreme examples of human inbreeding. People whose parents may have been third- or fourth-degree relatives, for example, weren’t looked at in this study, so the researchers can’t say anything about the effects of milder inbreeding. Ultimately, this is another step for research efforts into the prevalence and lasting effects of inbreeding. New genetic resources are making this kind of research easier and more accessible — before the advent of
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