On February 24th, biotech company Moderna announced that the 1st batch of its vaccine candidate, called mRNA-1273, had been shipped to the National Institute of Allergy and Infectious Diseases and will soon begin phase 1 clinical trials for the coronavirus
, including preclinical research and animal testing, human clinical trials and quality control. “Generally, we’re talking years if not decades in most scenarios,” says Kathleen Neuzil, director at the Center for Vaccine Development and Global Health at the University of Maryland School of Medicine.
Inovio just received a $9 million grant to develop a new Covid-19 vaccine from the Coalition for Epidemic Preparedness Innovations, on top of a previous $56 million grant to develop vaccines for other diseases. J. Joseph Kim, Inovio’s CEO, says he wants to have a Covid-19 vaccine in human trials in less than seven months. “We’re trying to move very rapidly into human testing in China,” Kim says.
Johnson & Johnson, which is repurposing a technology for the new coronavirus vaccine that was once successful for its Ebola and Zika vaccines, is “looking at 8 to 12 months” before the vaccine is publicly available, says the company’s chief scientific officer, Paul Stoffels. Though the process will take time, drugmakers still expect to move faster than they have with past outbreaks. One reason is due to advances in genome sequencing technology.
use modified DNA sequences delivered into human cells that trigger an immune response against specific pathogens. to produce than traditional vaccines. Moderna will use an mRNA vaccine to target a protein on the coronavirus surface that will also activate the immune system. There is a possibility that the current outbreak could be contained or be over before a vaccine is publicly available.
Coronaviruses are actually common viruses in humans, and most cause nothing more than a common cold. But in recent history there has been a rash of deadly outbreaks: Covid-19 is the third lethal coronavirus epidemic in the past two decades. It seems likely that even if we get this outbreak under control, another future outbreak will occur where a vaccine would be useful. ...
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