For this to have happened, two divergent viruses must have infected the same organism simultaneously.
shows that the genome of the coronavirus isolated from the Malaysian pangolin is less similar to SARS-Cov-2, with only 90 percent of genomic concordance. This would indicate that the virus isolated in the pangolin is not responsible for the COVID-19 epidemic currently raging.
However, the coronavirus isolated from pangolin is similar at 99 percent in a specific region of the S protein, which corresponds to the 74 amino acids involved in the ACE receptor binding domain—the one that allows the virus to enter human cells to infect them. By contrast, the virus RaTG13 isolated from batis highly divergent in this specific region .
This recombination mechanism had already been described in coronaviruses, in particular to explain the origin of SARS-CoV. It is important to know that recombination results in a new virus potentially capable of infecting a new host species. For recombination to occur, the two divergent viruses must have infected the same organism simultaneously.
Two questions remain unanswered: in which organism did this recombination occur? A bat, a pangolin or another species? And above all, under what conditions did this recombination take place?
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