A new insight into why some IVF embryos go into 'developmental arrest' could help researchers create treatments that coax them into growing normally
combined this with similar data on six other arrested embryos
They were surprised to find that the arrested embryos didn’t have higher rates of chromosome abnormalities than healthy embryos.Instead, they discovered that arrested embryos could be divided into three groups. In type 1, the embryo makes proteins from maternal RNA that had been in the egg, but fails to start making proteins from its own DNA, a crucial step in its development.
In type 2 arrested embryos, their oxygen-dependent metabolism continues, while in type 3, it falls to low levels, with neither correctly moving to a non-oxygen-dependent metabolism. Resveratrol seemed to restart development in about half the 42 arrested embryos. But most still stopped growing later on, with only three reaching the blastocyst stage. And even these didn’t seem to have normal gene activity, says Hutchins. “We’re sort of forcing them to develop, even though they really don’t want to,” he says.
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