Alyssa received genetically modified cells that could chase and kill the cancerous T-cells without attacking each other.
Leukemia is characterized by thethat takes place in the bone marrow. Chemotherapy is usually administered to kill all bone marrow cells, and then, the bone marrow is replaced with a transplant. While the approach is popular and successful in most cases, doctors try another method called CAR-T therapy, if the above fails.
Therefore, the teams involved in the process used base-editing, a technique that was invented only six years ago, to create a new type of CAR T-cell therapy to attack cancerous T-cells.Single letters of the DNA code are chemically converted to change the T-cells. The technique was used to make multiple changes to healthy donor T-cells.and changed so that they aren't attacked by the patient's immune system.
"This is a great demonstration of how, with expert teams and infrastructure, we can link cutting-edge technologies in the lab with real results in the hospital for patients. It's our most sophisticated cell engineering so far and paves the way for other new treatments and ultimately better futures for sick children," said Professor Waseem Qasim, Professor of Cell and Gene Therapy at UCL GOS ICH and Consultant Immunologist at GOSH.
Alyssa's mother hopes her daughter's treatment is proof the research works. "The doctors have said the first six months are the most important, and we don't want to get too cavalier, but we kept thinking 'If they can just get rid of it, just once, she'll be ok.' And maybe we'll be right," she said.
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