When people with metastatic breast cancer close their eyes at night, their cancer awakes and starts to spread.
That's the striking finding from a paper published inthis week that overturns the assumption that breast cancer metastasis happens at the same rate around the clock.The result may change the way that doctors collect blood samples from people with cancer in the future, the researchers say.
"Some of my colleagues work early in the morning or late in the evening; sometimes they'll also analyze blood at unusual hours,"Mice that seemed to have a much higher number of circulating cancer cells than humans provided another clue: Mice sleep during the day when blood samples are most often taken.
Interestingly, the cancer cells collected during the rest period were"highly prone to metastasize, whereas circulating tumor cells generated during the active phase are devoid of metastatic ability",Genetic analysis revealed that tumor cells taken from mice and humans at rest had upregulated their expression of mitotic genes. This makes them better at metastasizing as mitotic genes control cell division.
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