Modeling shows how genetic changes that don’t lead to changes in protein sequence can still alter protein function. New modeling shows how synonymous mutations — those that change the DNA sequence of a gene but not the sequence of the encoded protein — can still impact protein production and func
Illustration of a new class of protein misfolding called a non-covalent lasso entanglement that can result from changes to the rate of protein synthesis caused by synonymous mutations. Bottom: structure of a protein showing its native state and misfolded state with non-covalent lasso entanglement. Credit: Yang Jiang, Penn State
The results demonstrate the importance of kinetics — the rate of protein synthesis — in addition to sequence for determining protein structure and function and could have implications in fields such as biopharmaceutics for fine-tuning the activity of synthesized proteins. “We used to use ‘synonymous’ and ‘silent’ interchangeably to describe mutations that don’t change a protein’s sequence because it was thought that they wouldn’t alter the function of the protein,” said Ed O’Brien, professor of chemistry and a member of the Institute for Computational and Data Sciences at Penn State, and one of the leaders of the research team. “But, we’ve known for some time now that not all synonymous mutations are silent.
“In our models, we found a new class of protein misfolding that we call a ‘non-covalent lasso entanglement,’” said Jiang. “Essentially, a portion of the protein forms a closed loop, and one end of the protein incorrectly threads through the loop and gets trapped for long time periods.” These new insights into how the kinetics of protein synthesis can influence protein structure and function could have repercussions in fields ranging from biochemistry to biotechnology and to medicine.
Norge Siste Nytt, Norge Overskrifter
Similar News:Du kan også lese nyheter som ligner på denne som vi har samlet inn fra andre nyhetskilder.
Scientists Discover That Binge-Eating Sweet Treats Is Influenced by Gut MicrobiomeGut Microbes Influence Binge-Eating of Sweet Treats in Mice We have all been there. You just meant to have a single Oreo cookie as a snack, but then you find yourself going back for another, and another. Before you know it, you have finished off the entire package even though you were not all that
Les mer »
DNA analysis of soil from paw prints could help save Sumatra's tigers | CNNDr. Mrinalini Watsa, a researcher at San Diego Zoo, is developing an easy, cost-effective DNA analysis technique, using soil samples from the paw prints of 4-year-old Sumatran tiger Rakan. The application could one day help track endangered Sumatran tigers in the wild.
Les mer »
'Torso Killer' expected to plead guilty to 1968 murder, other 1970s killings in Nassau CountyThe Nassau District attorney says this DNA hit that led them to Cottingham is likely the oldest DNA hit to lead to a prosecution in this country.
Les mer »
Cyberpunk: Edgerunners Cosplay Shows Off Why Lucy's So PopularCyberpunk: Edgerunners was one of the most standout releases of the year overall, and one awesome [...]
Les mer »
Wander + Ivy’s single-serving premium wines are a massive hitWander + Ivy's single-serving premium wines are a massive hit
Les mer »