Nature research paper: Discovery of bioactive microbial gene products in inflammatory bowel disease
Extended Data Fig. 3 An integrated annotation approach characterizes millions of gut microbial protein families., We enumerated the degree to which annotations based on local homology or secondary structure could be assigned by MetaWIBELE. ‘InterPro signatures’ represents protein signatures in the InterPro except Pfam domains. ‘Interaction’ means domain-domain interactions as predicted by DOMINE. ‘Others’ includes other types of protein subcellular localization. .
). The first row indicates the number of genomes in RefSeq per genus. The second row indicates the mean relative abundance of known and novel proteins , in which red dots represent the mean of known proteins and blue dots represent the mean of novel proteins., Uncharacterized proteins expanded common gut taxa. Each clade represents one genus. Circle bars show relative abundance of different categories of protein families.
Extended Data Fig. 5 Essential genes are assigned higher priority scores using MetaWIBELE’s unsupervised approach., Prevalence and abundance of 1.6M protein families from the HMP2 metagenomes. Essential proteins were enriched in proteins prioritized by the harmonic mean of these values., When assumed to be true positives , essential proteins were notably well-predicted by ecological properties. This was true across a range of beta parameter settings: i.e.
Norge Siste Nytt, Norge Overskrifter
Similar News:Du kan også lese nyheter som ligner på denne som vi har samlet inn fra andre nyhetskilder.
Hoornstra: In MLB, there are signs that nature is healingAfter two years of pandemic-induced weirdness, a more normal version of baseball is back (with less parity than ever).
Les mer »
‘Love in the Jungle’ takes dating into nature: ‘It’s entertaining, it’s so different’“We had somewhat of an idea that animals would be incorporated and it would be different, but we didn’t know until the first day of filming that we couldn’t talk to each other,” Paige Dacanay, one of the series’ contestants told FOX.
Les mer »
Lidar reveals pre-Hispanic low-density urbanism in the Bolivian Amazon - NatureTwo remarkably large sites in southwest Amazonia, belonging to the Casarabe culture, include complex civic-ceremonial architecture and large water-management infrastructure, representing a type of tropical low-density urbanism that has not previously been described in Amazonia.
Les mer »
Enhanced silica export in a future ocean triggers global diatom decline - NatureMesocosm experiments in different biomes show that future ocean acidification will slow down the dissolution of biogenic silica, decreasing silicic acid availability in the surface ocean and triggering a global decline of diatoms as revealed by Earth system model simulations.
Les mer »
Generation of specialized blood vessels via lymphatic transdifferentiation - NatureA study of zebrafish identifies an innate mechanism of blood vessel formation through the transdifferentiation of lymphatic endothelial cells, and provides in vivo evidence for a link between cell ontogeny and functionality in endothelial cells.
Les mer »
A vaccine targeting resistant tumours by dual T cell plus NK cell attack - NatureA vaccine targeting stress proteins expressed by many cancers blocks a tumour escape mechanism, enabling protective immunity mediated by diverse T cell and NK cell populations.
Les mer »