Ovarian cancer can hide from even the best surgeons. A novel injectable tracer turns them fluorescent green, making them easier to spot and remove. [Sponsored by AmerChemSociety]
Surgeons who operate on patients with ovarian cancer face a tough challenge. They need to remove as much of a tumor as possible, but small cancerous nodules that spread from the ovaries into other organs can hide in folds of tissue, evading a surgeon’s trained eye. Finding them is critical, since the best outcomes for patients depend on leaving no cancer behind.
Surgeons already use a marker called indocyanine green, which glows brightly when exposed to near infrared light to improve the visibility of liver, lung, colon, and other cancers. Yet, indocyanine green does not bind to ovarian cancers with enough specificity for clinical applications. When the labeled antibody was released near ovarian cancer cells, its Y-shaped arms bound to the cells. The researchers then fused the labeled arms to the stem of a human antibody, generating a hybrid called a humanized mouse antibody. By attaching indocyanine green to this hybrid antibody, they generated a probe suitable for clinical use, Hooper says, because it can sneak past a patient's immune system.
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