Magic-mushroom drug can treat severe depression, trial suggests

In a trial, 25mg of psilocybin put patients in a dreamlike state, making therapy more likely to succeed.

, 1mg, 10mg and 25mg doses were tested on a total of 233 people from 10 countries in Europe and North America, with 25mg giving the best results.Most had been severely depressed for more than a year and were aged around 40, the researchers, from the Institute of Psychiatry, Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust, said.

"Patients go from 'What is wrong with me?' to 'What happened to me?'" psychotherapist Nadav Liam Modlin said. University of Edinburgh head of psychiatry Prof Andrew McIntosh said the trial provided "the strongest evidence so far to suggest that further, larger and longer randomised trials of psychedelics are justified".

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