A single dose of psilocybin, the hallucinogenic compound found in “magic mushrooms,” was found to help some people who previously had gotten little relief from standard antidepressants.
The medicinal use of hallucinogenic mushrooms is making inroads in U.S. states as many advocate for the therapeutic value of psychedelic drugs.
with major depression battle symptoms, such as persistent feelings of sadness, angry outbursts, low energy, and suicidal thoughts, that don’t respond to medication. the New England Journal of Medicine The trial participants listened to a specially-designed music playlist and wore an eye mask to help direct attention inward as the psilocybin took hold, while in a room designed to be a "nonclinical and calming atmosphere." The psychedelic effects lasted between 6 to 8 hours, and during this time an experienced therapist was in the room to offer support.
Nearly a third of the 25-mg dose group reported significant improvements in their depression, compared to 9% and 8% of the 10-mg and 1-mg groups, respectively. Dr. James Rucker, a consultant psychiatrist at South London and Maudsley NHS foundation trust, who worked on the trial at King’s College London, said the study was by far the largest clinical trial on the use of psilocybin for treatment-resistant depression to date.
Researchers must obtain special approval to conduct studies of Schedule I controlled substances in the U.S. Overall, more than 180 studies of psilocybin and other psychedelics for use in depression, PTSD, and other mental conditions are currently listed on the National Library of MedicineIn 2018, Compass Pathways received U.S. Food and Drug Administration approval of "breakthrough therapy" status for the psilocybin treatment developed for depression.
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