Updated Reference: Antibody drug conjugate trastuzumab deruxtecan is the first HER2-directed treatment for unresectable or metastatic HER2-mutant NSCLC.
Non–small cell lung cancer. Prognostic factors for lung cancer.A retrospective Surveillance, Epidemiology, and End Results data analysis suggests that the number of nodes with cancer may be predictive of survival. Mean lung cancer-specific survival decreased from 8.8 years for patients with one positive lymph node to 3.9 years for patients with more than eight positive lymph nodes.Patients with in situ and stage I lung cancer may respond to surgery.
In patients younger than 70 years, high-risk patients, with the shortest recurrence-free survival, demonstrated increased activation of the Src and tumor necrosis factor pathways. Multivariate analyses confirmed the independent clinical relevance of the pathway-based subphenotypes in women and patients younger than 70 years.
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