A high-tech cell therapy used to treat cancer has been repurposed as a treatment for lupus, an autoimmune condition that can cause joint, kidney and heart damage.
CAR T-cell therapy has put all five people with lupus treated so far into remission. The participants have been followed up for an average of 8 months, with the first person treated 17 months ago.
It is currently treated with medicines that suppress the immune system or, in more severe cases, with. But the treatments can’t kill all the B cells, and if the disease flares up badly, some people develop kidney failure and inflammation of their heart and brain. The CAR T-cells were barely detectable after one month, and after three and a half months, the volunteers’ B cells started to return, having been produced by stem cells in bone marrow. These new B cells didn’t react against the DNA.
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