The alarming rise in the frequency of hypospadias, the most common genital malformation in male infants, is believed to be caused by environmental factors such as exposure to toxic substances that alter epigenetic programming in the developing penis. A recent study published in Science Reports ha
Hypospadias is a congenital abnormality in males where the opening of the urethra is not located at the tip of the penis. Instead, it is located on the underside of the penis or even in the scrotum.
The research helps answer long-standing questions surrounding the increased frequency and potential root cause of hypospadias, a birth defect in which the opening of the urethra is located on the underside of the penis instead of the tip. One potential path forward would be to identify a specific epigenetic biomarker that could be collected with a simple cheek swab from the parents of a baby to determine the likelihood of the newborn developing a hypospadia.
One potential culprit the researchers mentioned in the study is a pharmaceutical drug called diethylstilbestrol that was used in the late 50s and early 60s to ease the later stages of pregnancy for women.
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