Scientists discover a new kind of celldeath linked to copper broadinstitute sciencemagazine
as a potential cancer drug, but it failed to show efficacy in patients, as it was not known at the time how this molecule works. However, the researchers knew from their experiments that the copper-bound molecules kill cells—and that this kind of cell death is different from other known forms of cell death pathways.
Next, the team homed in on how these copper carriers kill cells. They found that cells that relied on mitochondria to produce energy were nearly 1,000 times more sensitive to copper ionophores than cells that use glucose processing. Using multiple CRISPR knockout screens, the team identified key genes that facilitate copper-induced death.
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