Nature research paper: Transcriptional coupling of distant regulatory genes in living embryos
) along the scyl/chrb loci is shown below for the control line and the tether deletion . Note the similar insulation landscape outside of the replaced region., Virtual 4C contact maps computed based on Micro-C data for the control line , a line with the knrl tethering elements replaced , a line with an extended replacement of the knrl tethers encompassing also the adjacent CTCF , a line with kni tethering element replaced . The viewpoint is anchored on the kni tethering element region .
The viewpoint is anchored on the chrb tethering element region . Interaction frequency over the scyl upstream region is significantly reduced in the mutant compared to wt ., but with viewpoint anchored on the knrl tethers. Interaction frequency over the kni promoter-proximal region is reduced in all mutants compared to wt . Inset shows data for a slightly shifted viewpoint , from the adjacent shared enhancer, as in Extended Data Fig.
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