Scientists have gleaned new insights into how psychedelics alter conscious experience via their action on brain activity. In a study at Imperial College London, detailed brain imaging data from 20 healthy volunteers revealed how the potent psychedelic compound, DMT (dimethyltryptamine), alters br
A study at Imperial College London examined the effects of DMT , a potent psychedelic compound, on brain function using detailed brain imaging data from 20 healthy volunteers. The results, published in the journal PNAS, showed increased connectivity across the brain and enhanced communication between various areas and systems, particularly in regions associated with higher-level functions like imagination.
“One increasingly popular view is that much of brain function is concerned with modelling or predicting its environment. Humans have unusually big brains and model an unusually large amount of the world. For example, like with optical illusions, when we’re looking at something, some of what we’re actually seeing is our brain filling in the blanks based on what we already know.
Volunteers received a high dose of DMT , while simultaneously undergoing two types of brain imaging: functional magnetic resonance imaging and electroencephalography . The total psychedelic experience lasted about 20 minutes, and at regular intervals, volunteers provided a rating of the subjective intensity of their experience .
Prof Robin Carhart-Harris, founder of the Centre for Psychedelic Research at Imperial College London, and senior author on the paper , commented: “Motivated by, and building on our previous research with psychedelics, the present work combined two complementary methods for imaging the brain imaging. fMRI allowed us to see the whole of the brain, including its deepest structures, and EEG helped us view the brain’s fine-grained rhythmic activity.
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