Scientists uncover the genes essential for the unusual lifestyle of minuscule bacteria that live on the surface of larger bacteria. Patescibacteria are a mysterious group of minute microbes with elusive survival methods. While scientists can only cultivate a handful of these types, they are part of
A scanning electron micrograph shows small purple Patescibacteria cells growing on the surface of much larger cells. New research led by Joseph Mougous’ lab at UW Medicine in Seattle reveals their lifecycle, their genes, and some of the molecular mechanisms that may be behind their unusual lifestyle. These epibiotic bacteria are Southlakia epibionticum.
The few types of Patescibacteria that researchers can grow in the lab reside on the cell surfaces of another, larger host-microbe. Patescibacteria in general lack the genes required to make many molecules necessary for life, such as the. This has led researchers to speculate that many of them rely on other bacteria to grow., researchers present the first glimpse into the molecular mechanisms behind the unusual Patescibacteria lifestyle.
“The ability to genetically perturb Patescibacteria opens up the possibility of applying a powerful systems analysis lens to rapidly characterize the unique biology of obligate epibionts,” he added, in reference to organisms that must live on another organism to survive.University of Washington Microbial dark matter is likely to contain information about biochemical pathways with potential biotechnology applications, according to thepaper. It also holds clues to the molecular activities that support a microbial ecosystem, as well as to the cell biology of the assorted microbial species gathered in that system.
Yaxi Wang, an epibiotic bacteria researcher, at an anaerobic workstation in a microbiology lab at the University of Washington School of Medicine in Seattle. Credit: S. Brook Peterson/University of Washington Another application of the authors’ work was the generation of Saccharibacteria cells that express fluorescent proteins. With these cells, the researchers performed time-lapse microscopic fluorescent imaging of Saccharibacteria growing with their host bacteria.
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