New research attributes the cognitive benefits of young blood, exercise, and the longevity hormone klotho to platelets. In a remarkable convergence, scientists have discovered that the same blood factor is responsible for the cognitive enhancement that results from young blood transfusion, the long
, identify platelet factor 4 as a common messenger of each of these interventions.
“When we realized we had independently and serendipitously found the same thing, our jaws dropped,” Dubal said. “The fact that three separate interventions converged on platelet factors truly highlights the validity and reproducibility of this biology. The time has come to pursue platelet factors in brain health and cognitive enhancement.”Villeda is an expert on parabiosis, an experiment in which two animals are linked together by their blood circulation.
PF4 had a dramatic effect on the hippocampus, the brain region responsible for making memories, where it enhanced the formation of new neural connections at the molecular level.
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